Textbook of Malignant Hematology by Laurent Degos, David C. Linch, Bob Lowenberg

Textbook of Malignant Hematology



Download Textbook of Malignant Hematology




Textbook of Malignant Hematology Laurent Degos, David C. Linch, Bob Lowenberg
Language: English
Page: 800
Format: pdf
ISBN: 1841841455, 9780203339886
Publisher:

From The New England Journal of Medicine

Advances in genetic research are playing an important part in the quest for a fundamental understanding of the basis of cancer in humans. Carcinogenesis is thought to be a somatic evolutionary process that is driven by a combination of genetic alterations and selection. The development of methods to detect and measure molecular alterations has already proved important in the cure of specific kinds of cancer. Early diagnosis and detection of relapse, together with accurate prognosis, are crucial to the effective treatment of cancer. In the past two decades, remarkable progress has been made in increasing survival rates among children and adults with certain types of leukemia and lymphoma.

The Texbook of Malignant Haematology is a valuable resource for physicians interested in learning about hematologic neoplasms. It covers basic cellular and molecular aspects of hematopoiesis, developments in therapy, and the perplexities caused by specific diseases. Clinical observations, treatments, and outcomes for individual hematopoietic cancers are described in detail, with different chapters dealing with pediatric or adult cancers, when appropriate.

The book begins with a comprehensive review of the cellular and genetic aspects of hematopoiesis. The interplay among cytokines, their cellular receptors, and transcription factors influences the cell cycle and regulates hematopoiesis. Studies of the activation and signaling of receptors are relevant to the molecular basis of hematologic disorders, and these pathways are viewed as targets for new therapeutic interventions.

An important section of the book deals with the association of acquired genetic alterations with hematologic disorders. Initially identified by conventional cytogenetic methods, these alterations have now been characterized at the molecular level. Evaluation of many of the chromosomal rearrangements found in hematologic cancers has led to the identification of target genes involved in leukemogenesis. Most of these target genes encode transcription factors that are important in development and differentiation; when altered, these genes can disrupt the regulation of gene activation or join to create a fusion gene. Most fusion genes encode chimeric, tumor-specific proteins. The detection of fusion genes or their transcripts by methods based on the reverse-transcriptase polymerase chain reaction can be used to diagnose a disease or identify neoplastic cells that remain after treatment.

The associations between particular cytogenetic or molecular changes and distinct subtypes of a neoplasm or treatment outcome are highlighted in various chapters. Many of the chromosomal abnormalities that are important in classifying leukemias and lymphomas are also used to stratify therapy.

Another section of the book describes current therapies for hematologic cancers. Allogeneic bone marrow transplantation is extensively reviewed, and up-to-date information, including information about cord-blood transplantation and the use of mismatched related and unrelated donors, is provided. The section on autologous stem-cell transplantation focuses on the technique for stem-cell manipulation. Indications for and outcomes of autologous transplantation are covered in the sections on individual hematologic diseases.

New therapies to manipulate the immune system so as to improve the treatment of hematologic diseases are being developed. Several chapters review the biologic basis of humoral and cellular immunotherapy and the current clinical trials of these methods. There is also an overview of genetic manipulation and gene therapy.

The reference section in each chapter contains a large bibliography, which lists up-to-date reviews of important research and directs the reader to selected areas of interest. Tables in the appendixes provide information about lineage-associated antigens and cytokines involved in human hematopoiesis and refer to information summarized in the chapters.

I recommend this book as a reference for medical libraries and a resource for researchers, medical professionals, and students in the field of hematologic cancers.

Reviewed by Susana C. Raimondi, Ph.D.
Copyright © 1999 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.
--This text refers to an alternate

edition.

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